Prescription RequiredCompoundedCVShingles Relief Cream
This compounded cream combines gabapentin, ketoprofen, amitriptyline, lidocaine, and acyclovir to help ease the pain, burning, and itching that often come with shingles (herpes zoster). The blend targets nerve pain, reduces inflammation, numbs the skin, and delivers an antiviral effect right where the rash appears. It is made for topical use only and is not meant to treat shingles systemically. Always use exactly as prescribed by your healthcare provider.
Requires a valid prescription from your provider. Not sure if it's right for you? Ask a pharmacist.
These statements have not been evaluated by the Food and Drug Administration. Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This information is for educational purposes only and is not medical advice — always consult your healthcare provider before starting any new treatment.
Clinical information
Medication information for patients and providers.
A valid prescription from a DEA-registered prescriber is required.
Limited to 5 refills within 6 months of the original prescription date.
Subject to state and federal controlled-substance regulations.
Use as directed by your healthcare provider. Apply a thin layer to the affected skin 3 to 4 times daily. Gently massage for several minutes until absorbed. Wash hands after use unless treating them. If you miss a dose, apply it when you remember unless it is almost time for your next application. Do not apply two doses at once.
Gabapentin calms over-active nerve signals that cause shooting pain. Ketoprofen blocks substances called prostaglandins that create swelling and soreness. Amitriptyline raises certain nerve messengers that reduce pain signals in the skin. Lidocaine briefly stops sodium channels in nerves, creating a numbing effect within 15–30 minutes that can last 2–3 hours. Acyclovir stops the shingles virus from making new copies in skin cells, helping the rash heal. Most people feel less burning within a few days, while full pain relief may take 1–2 weeks of regular use. The antiviral benefit is strongest when used early in an outbreak.
Do not use if you are allergic to gabapentin, ketoprofen, amitriptyline, lidocaine, acyclovir, other NSAIDs, tricyclic antidepressants, local anesthetics, or any cream ingredients (such as the base). Do not apply to open wounds, broken skin, or mucous membranes. Avoid if you have a history of severe asthma triggered by NSAIDs, active skin infection needing oral treatment, or methemoglobinemia. Not for use in children under 12 unless specifically directed by a pediatric specialist. Pregnant or breastfeeding individuals should consult their healthcare provider before use because safety data are limited.
Because the cream works mainly on the skin, most interactions are unlikely, but small amounts can enter the bloodstream. Using other topical NSAIDs or oral NSAIDs (like ibuprofen, naproxen) may raise risk of skin irritation or systemic side effects such as stomach upset. Taking strong depression medicines (such as MAOIs) with amitriptyline may heighten drowsiness. Large use of other products containing lidocaine (patches, gels) can increase numbness or heart rhythm effects. Tell your provider about prescription drugs, over-the-counter medicines, herbal supplements (especially St. John’s wort or kava), and alcohol use. Avoid covering the treated area with tight dressings or heating pads, which can boost absorption.
Very common (more than 1 in 10 people): mild redness, temporary burning or tingling at the application site; usually improves within 30 minutes. Common (1–10 in 100 people): itching, dry skin, slight numbness that lasts longer than expected, mild drowsiness. Uncommon (1–10 in 1,000 people): skin rash away from treated area, swelling, headache, stomach upset. Rare but serious: severe allergic reaction with hives or breathing trouble, bluish skin or lips (sign of methemoglobinemia), unusual bleeding or bruising. Most local reactions get better when the cream is stopped. Seek medical help right away for severe or persistent side effects.
Store tightly closed at room temperature 68–77°F (20–25°C). Keep away from heat, high humidity, and direct sunlight. Do not freeze. Keep out of reach of children and pets. Do not use after the labeled expiration date. Dispose of leftover or expired cream through a pharmacy take-back program or mix with coffee grounds in a sealed bag before throwing it in the household trash.
Frequently asked questions.
Many people feel a mild numbing effect within 30 minutes because of lidocaine. Deeper nerve pain relief often builds over several days of regular use, with best results after 1–2 weeks.
Yes, the cream is often used together with oral antivirals or pain pills. Tell your healthcare provider everything you are taking so they can watch for overlapping side effects.
Leave the skin open to air unless your provider tells you to cover it. Tight dressings, heating pads, or plastic wrap can make too much medicine absorb, which may increase side effects.
A brief, mild sting is common and usually fades quickly. If burning lasts longer than 30 minutes, becomes severe, or the skin looks worse, wash the area with mild soap and water and call your healthcare provider.
The cream itself does not affect driving, but a small amount of amitriptyline can sometimes cause drowsiness. If you feel sleepy or light-headed, wait until you feel alert before driving.
Keep the tube tightly closed when not in use and store it in a cool, dry place away from bathrooms and kitchens. Do not transfer it to another container; use it directly from the original tube.
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